Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimers Disease
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چکیده
منابع مشابه
Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimer's Disease
BACKGROUND There are several reports indicating a decrease of ethanolamine plasmalogen (pl-PE) in brain tissues and in serum of patients with Alzheimer's disease (AD). The present study aimed to examine the composition of erythrocyte phospholipids including pl-PE in patients with AD. METHOD A high-performance liquid chromatography (HPLC) method that can separate intact plasmalogens and all ot...
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The microviscosity and fluidity of erythrocyte ghost membranes from lead workers and control subjects was measured by fluorescence polarisation using the fluorophore, 1,6-diphenyl-1,3,5-hexatriene (DPH). Increased lead was associated with a significant decrease in the average microviscosity of resealed and unsealed erythrocyte membranes. Since DPH fluorescence reflects the organisation of lipid...
متن کاملInfluence of pH on phospholipid redistribution in human erythrocyte membrane.
The influence of the suspension pH (pHo) on the transmembrane mobility of spin-labeled phospholipid analogues in the human red blood cell was investigated. The passive transverse diffusion of spin-labeled phospholipid analogues was independent of pHo in the investigated range (5.8 to 8.5). However, upon acidification to pHo 5.8, a significant decrease of the rapid adenosine triphosphate (ATP)-d...
متن کاملErythrocyte Phospholipid and Polyunsaturated Fatty Acid Composition in Diabetic Retinopathy
BACKGROUND Long chain polyunsaturated fatty acids (LCPUFAs) including docosahexaenoic acid and arachidonic acid are suspected to play a key role in the pathogenesis of diabetes. LCPUFAs are known to be preferentially concentrated in specific phospholipids termed as plasmalogens. This study was aimed to highlight potential changes in the metabolism of phospholipids, and particularly plasmalogens...
متن کاملChanges in composition and properties of erythrocyte membrane in chronic alcoholics.
AIMS AND METHODS Alterations in cholesterol and phospholipid contents as well as fluidity and lipid peroxidation in erythrocyte membranes from chronic alcoholic humans were investigated. RESULTS While an increase in cholesterol with no change in phospholipid content was observed in erythrocyte membranes, the phospholipid content increased with no change in cholesterol in plasma. CONCLUSIONS...
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ژورنال
عنوان ژورنال: Dementia and Geriatric Cognitive Disorders Extra
سال: 2012
ISSN: 1664-5464
DOI: 10.1159/000341603